|
KMID : 1123920140280060657
|
|
Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 6 p.657 ~ p.661
|
|
|
Report on Two Cases of Gilbert’s Syndrome Found in the Process of Administering Herbs
|
|
Lee Jong-Deok
Kim Dong-Woung
|
|
|
Abstract
|
|
|
|
Gilbert’s syndrome is one that shows a benign course with intermittent unconjugate hyperbilirubinemia without any evidence of hepatobiliary tract disease or hemolysis. It is often found in a health examination or blood laboratory test by chance. In particular, patients who are taking drugs, including herbal medicine should be careful for their medication due to the possibility of associations with changes in liver function because of drug metabolism, sometimes they have to quit the use of the medication for a certain period and often they should get an additional test. Two male patients increased serum total bilirubin level without other systemic symptoms in screening test for clinical herb medicine pharmacokinetics study. Therefor they was diagnosed with suspected Gilbert’s syndrome. They had been calory deprivation test with 24 hours fasting state. They also performed liver function test and ultrasonogram for evaluation of hepatobiliary tract disease. Total serum bilirubin was markedly increased, especially unconjugate bilirubin level higher over the two times than base line after they had been calory deprivation for 24 hours, They was not found another abnormality all laboratory results and physical examination. This study is a report on two cases of hyperbilirubinemia, diagnosed as Gilbert’s syndrome, which were found in the process of a clinical pharmacokinetic study of a decoction of medicinal herbs.
|
|
|
KEYWORD
|
|
|
Gilbert’s syndrome, Hyperbilirubinemia, Herb medicine
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|